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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PKN3 All Species: 25.76
Human Site: S299 Identified Species: 40.48
UniProt: Q6P5Z2 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q6P5Z2 NP_037487.2 889 99421 S299 L T A V P G R S P A A A L A S
Chimpanzee Pan troglodytes XP_001159776 886 99121 S299 L T A V P G R S P A A A L A S
Rhesus Macaque Macaca mulatta XP_001110500 1011 111864 S412 L A A V P G R S P A A A L A G
Dog Lupus familis XP_548434 951 104664 S361 L K A V P G R S P A A A L A G
Cat Felis silvestris
Mouse Mus musculus Q8K045 878 97863 S292 L V A V P G R S P M A V L A G
Rat Rattus norvegicus O08874 985 112050 S350 W E N V P G R S K A T S V A L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506565 993 109767 S399 L R A V P G R S R V A T V L G
Chicken Gallus gallus XP_422357 1013 114806 S375 L E N V P G R S K A T S V T L
Frog Xenopus laevis Q7ZX15 486 56292
Zebra Danio Brachydanio rerio XP_697542 940 106140 C338 L E S V P G R C R V S N M S S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P13678 634 71138 K155 R F V V H S Y K R F T F C D H
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34885 707 80133 C212 T V V V H K R C H E D V V W K
Sea Urchin Strong. purpuratus XP_787090 799 90414 S210 R S S S R S S S T K E E I S N
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P24583 1151 131500 A287 N D S L I P V A I M W L L L S
Red Bread Mold Neurospora crassa P87253 1142 127954 A373 P P Q F P M G A Q S P Q F A A
Conservation
Percent
Protein Identity: 100 97.7 81.5 84.2 N.A. 83.2 49.9 N.A. 64.2 48.9 26.2 52.2 N.A. 28 N.A. 29.1 41.5
Protein Similarity: 100 97.8 82.9 87.6 N.A. 88.4 63.6 N.A. 72.9 63 36.6 67.6 N.A. 41.5 N.A. 43.9 58.2
P-Site Identity: 100 100 86.6 86.6 N.A. 73.3 46.6 N.A. 53.3 46.6 0 40 N.A. 6.6 N.A. 13.3 6.6
P-Site Similarity: 100 100 86.6 86.6 N.A. 73.3 60 N.A. 60 60 0 66.6 N.A. 6.6 N.A. 20 40
Percent
Protein Identity: N.A. N.A. N.A. N.A. 25.2 27.1
Protein Similarity: N.A. N.A. N.A. N.A. 41.7 43.2
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 13.3
P-Site Similarity: N.A. N.A. N.A. N.A. 33.3 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 40 0 0 0 0 14 0 40 40 27 0 47 7 % A
% Cys: 0 0 0 0 0 0 0 14 0 0 0 0 7 0 0 % C
% Asp: 0 7 0 0 0 0 0 0 0 0 7 0 0 7 0 % D
% Glu: 0 20 0 0 0 0 0 0 0 7 7 7 0 0 0 % E
% Phe: 0 7 0 7 0 0 0 0 0 7 0 7 7 0 0 % F
% Gly: 0 0 0 0 0 60 7 0 0 0 0 0 0 0 27 % G
% His: 0 0 0 0 14 0 0 0 7 0 0 0 0 0 7 % H
% Ile: 0 0 0 0 7 0 0 0 7 0 0 0 7 0 0 % I
% Lys: 0 7 0 0 0 7 0 7 14 7 0 0 0 0 7 % K
% Leu: 54 0 0 7 0 0 0 0 0 0 0 7 40 14 14 % L
% Met: 0 0 0 0 0 7 0 0 0 14 0 0 7 0 0 % M
% Asn: 7 0 14 0 0 0 0 0 0 0 0 7 0 0 7 % N
% Pro: 7 7 0 0 67 7 0 0 34 0 7 0 0 0 0 % P
% Gln: 0 0 7 0 0 0 0 0 7 0 0 7 0 0 0 % Q
% Arg: 14 7 0 0 7 0 67 0 20 0 0 0 0 0 0 % R
% Ser: 0 7 20 7 0 14 7 60 0 7 7 14 0 14 27 % S
% Thr: 7 14 0 0 0 0 0 0 7 0 20 7 0 7 0 % T
% Val: 0 14 14 74 0 0 7 0 0 14 0 14 27 0 0 % V
% Trp: 7 0 0 0 0 0 0 0 0 0 7 0 0 7 0 % W
% Tyr: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _